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Runes in Divinity: Original Sin 2 can be found on this page. You can enchant Weapons and Armor with Runes to increase their effectiveness. You can also combine Runes to make a more powerful version. For example if you combine 2 Small Frost Runes with pixie dust, you will gain 1 Medium Frost Rune.

 

Runes

Final Product

Ingredient 1

Ingredient 2

Ingredient 3

Weapon Slot Effects

Armor Slot Effects

Amulet Slot Effects

 Small Flame Rune Wood Any Oil Source Pixie Dust +9% damage as Fire damage Fire Resistance: +6% Critical Chance: +3%
 Small Thunder Rune Water Gold Pixie Dust +9% damage as Air damage Air Resistance +6%  Dodging: +3%
 Small Frost Rune Water Metal Pixie Dust +9% damage as Water damage Water Resistance: +6% Movement: +0.25
 Small Rock Rune Rock Beer Pixie Dust +9% damage as Earth damage Earth Resistance: +6% Maximum Vitality: +11
 Small Venom Rune Bone Poison Pixie Dust +9% damage as Poison damage Poison Resistance: +6% Accuracy: +5%
 Small Masterwork Rune Livewood Log Wine Pixie Dust +9% damage as Physical damage  Maximum Physical Armour: +10%  Maximum Magic Armour: +10%
 Medium Flame Rune  Small Flame Rune  Small Flame Rune Pixie Dust +11% damage as Fire damage Fire Resistance: +9% Critical Chance: +6%
 Medium Thunder Rune  Small Thunder Rune  Small Thunder Rune Pixie Dust +11% damage as Air damage Air Resistance: +9% Dodging: +4%
 Medium Frost Rune  Small Frost Rune  Small Frost Rune Pixie Dust +11% damage as Water damage Water Resistance: +9% Movement: +0.5
 Medium Rock Rune  Small Rock Rune  Small Rock Rune Pixie Dust +11% damage as Earth damage Earth Resistance: +9% Maximum Vitality: +28
 Medium Venom Rune  Small Venom Rune  Small Venom Rune Pixie Dust +11% damage as Poison damage Poison Resistance: +9% Accuracy: +8%
 Medium Masterwork Rune  Small Masterwork Rune  Small Masterwork Rune Pixie Dust +11% damage as Physical damage Maximum Physical Armour: +20% Maximum Magic Armour: +20%
 Large Flame Rune  Medium Flame Rune  Medium Flame Rune Pixie Dust  +13% damage as Fire damage Fire Resistance: +12% Critical Chance: +9%
 Large Thunder Rune  Medium Thunder Rune  Medium Thunder Rune Pixie Dust  +13% damage as Air damage Air Resistance: +12%  Dodging: +5%
 Large Frost Rune  Medium Frost Rune  Medium Frost Rune Pixie Dust +13% damage as Water damage Water Resistance: +12% Movement: +0.75
 Large Rock Rune  Medium Rock Rune  Medium Rock Rune Pixie Dust +13% damage as Earth damage Earth Resistance: +12% Maximum Vitality: +84
 Large Venom Rune  Medium Venom Rune  Medium Venom Rune Pixie Dust +13% damage as Poison damage Poison Resistance: +12% Accuracy: +8%
 Large Masterwork Rune  Medium Masterwork Rune  Medium Masterwork Rune Pixie Dust +13% damage as Physical damage  Maximum Physical Armour: +30%  Maximum Magic Armour: +30%
 Giant Flame Rune  Large Flame Rune  Large Flame Rune Pouch Of Superior Pixie Dust  +15% damage as Fire damage Fire Resistance: +15% Critical Chance: +12%
 Giant Thunder Rune  Large Thunder Rune  Large Thunder Rune Pouch Of Superior Pixie Dust +15% damage as Air damage Air Resistance: +15% Dodging: +6%
 Giant Frost Rune  Large Frost Rune  Large Frost Rune Pouch Of Superior Pixie Dust +15% damage as Water damage Water Resistance: +15% Movement: +1
 Giant Rock Rune  Large Rock Rune  Large Rock Rune Pouch Of Superior Pixie Dust +15% damage as Earth damage Earth Resistance: +15% Maximum vitality: +203
 Giant Venom Rune  Large Venom Rune  Large Venom Rune Pouch Of Superior Pixie Dust +15% damage as Poison damage Poison Resistance: +15% Accuracy: +16%
Giant Masterwork Rune  Large Masterwork Rune  Large Masterwork Rune Pouch Of Superior Pixie Dust +15% damage as Physical damage Maximum Physical Armour: +40% Maximum Magic Armour: +40%
Small Flame Rune Of Power  Small Flame Rune Rune Frame Of Power        
Medium Flame Rune Of Power  Medium Flame Rune Rune Frame Of Power        
Large Flame Rune Of Power  Large Flame Rune Rune Frame Of Power        
Small Frost Rune Of Power  Small Frost Rune Rune Frame Of Power        
Medium Frost Rune Of Power  Medium Frost Rune Rune Frame Of Power        
Large Frost Rune Of Power  Large Frost Rune Rune Frame Of Power        
Small Thunder Rune Of Power

 Small Thunder Rune

Rune Frame Of Power        
Medium Thunder Rune Of Power

 Medium Thunder Rune

Rune Frame Of Power        
Large Thunder Rune Of Power

 Large Thunder Rune

Rune Frame Of Power        
Small Rock Rune Of Power

 Small Rock Rune

Rune Frame Of Power        
Medium Rock Rune Of Power  Medium Rock Rune Rune Frame Of Power        
Large Rock Rune Of Power  Large Rock Rune Rune Frame Of Power        
Small Venom Rune Of Power  Small Venom Rune Rune Frame Of Power        
Medium Venom Rune Of Power  Medium Venom Rune Rune Frame Of Power        
Large Venom Rune Of Power  Large Venom Rune Rune Frame Of Power        
Mystical Giant Flame Rune Mystical Rune Frame Giant Flame Rune   Ranged: +1 Huntsman: +1 Pyrokinetic: +1
+15% damage as Fire damage Fire Resistance +15% Critical Chance: +12%
Mystical Giant Thunder Rune Mystical Rune Frame Giant Thunder Rune   Dual Wielding: +1 Scoundrel: +1 Aerothurge: +1
+11% damage as Air damage Water Resistance: +15% Movement: +1
Mystical Giant Venom Rune Mystical Rune Frame Giant Venom Rune   Perserverance: +1 Summoning: +1 Necromancer: +1
+15% damage as Poison damage Poison Resistance: +15% Accuracy: +16%
Mystical Giant Frost Rune Mystical Rune Frame Giant Frost Rune   Single-Handed: +1 Leadership: +1 Hydrosophist: +1
+15% damage as Water damage Air Resistance: +15% Dodging: +6%
Mystical Giant Masterwork Rune Mystical Rune Frame Giant Masterwork Rune   Wits: +3 Constitution: +3 Memory: +3
+15% damage as Physical damage Maximum Physical Armour +40% Maximum Magic Armour: +40%
Mystical Giant Rock Rune Mystical Rune Frame Giant Rock Rune   Two-Handed: +1 Warfare: +1 Geomancer: +1
+15% damage as Earth damage Earth Resistance: +15% Maximum Vitality: +203
Giant Flame Rune of Power Rune Frame of Power Giant Flame Rune   Intelligence: +3 Intelligence: +3 Intelligence: +3
+15% damage as Fire Damage Fire Resistance: +15% Critical Chance: +12%
Giant Thunder Rune of Power Rune Frame of Power Giant Thunder Rune   Finesse: +3 Finesse: +3 Finesse: +3
+11% damage as Air damage Water Resistance: +15% Dodging: +6%
Giant Venom Rune of Power Rune Frame of Power Giant Venom Rune   Finesse: +3 Finesse: +3 Finesse: +3
+15% damage as Poison damage Poison Resistance: +15% Accuracy: +15%
Giant Frost Rune of Power Rune Frame of Power Giant Frost Rune   Intelligence: +3 Intelligence: +3 Intelligence: +3
+11% damage as Water damage Air Resistance: +15% Dodge: +6%
Giant Masterwork Rune of Power Rune Frame of Power Giant Masterwork Rune   Strength: +3 Strength: +3 Strength: +3
+15% damage as Physical damage Maximum Physical Armour: +40% Maximum Magic Armour: +40%
Giant Rock Rune of Power Rune Frame of Power Giant Rock Rune   Strength: +3 Strength: +3 Strength: +3
15% damage as Earth damage Earth Resistance: +15% Maximum vitality: +203

 




    • Anonymous

      01 Dec 2017 17:31  

      Does the +crit from Flame Runes give spells the ability to crit, or does one still need to pick up the talent?

      • Anonymous

        28 Oct 2017 01:20  

        The latest patch has fixed the framed runes of power amulet traits between frost and thunder (they were swapped), but has not fixed the weapon damage bonuses. In addition the flame rune of power is +9% fire damage.

        • Anonymous

          22 Oct 2017 23:50  

          Giant Flame Rune while Mystical/Rune of Power seems to be bugged to only provide +9% flame damage instead of the +15% the actual rune should provide. Don't use it if you want the fire damage, Fire Resistance is correct at 15% and Critical is correct at 12% (check the stats when equipped so it's not just the text).

          • Anonymous

            15 Oct 2017 06:27  

            I finally realized that Runes/Source Orbs can be extracted from gears when I am lvl18, don't be a silly like me. :(

            • Anonymous

              14 Oct 2017 04:28  

              Mystical Giant Venom Rune gives 15% accuracy, not 16%. It gives 1% less than its previous state, namely the simple Giant Venom Rune.

              • Anonymous

                13 Oct 2017 18:05  

                There was a mistake with 2 runes (at least), changed it.

                Giant Frost Rune of Power - 15% Air resistance
                Giant Thunder Rune of Power - 15% Water Resistance

                • Anonymous

                  10 Oct 2017 09:48  

                  mystical rune plus giant frost rune for some reason gives +6% dodging instead of its own property +1movement at least in recent patch ,fixed it on the table

                  • Anonymous

                    07 Oct 2017 22:07  

                    Bought 2x Superior Pixie Dust Pouch from potion vendor at Driftwood Market Place, each for 1800 gold. 44% discount from bartering 7 and 100% attitude (just gift some 100s gold to the trader).

                    • Anonymous

                      07 Oct 2017 16:55  

                      Can anyone tell me what Metal items work for where it says Metal + Water + Pixie dust. I have tried a bunch of different items and no luck, but i dont want to use something valuable if something cheap will do the trick.

                      • Anonymous

                        04 Oct 2017 20:00  

                        there are some mistakes, regarding the last columns, some stats are switched : mystical/power of giant frost runes / giant thunder runes
                        Frost runes give movement and thunder give dodging.

                        • Anonymous

                          27 Sep 2017 11:15  

                          when upgrading a rune to a rune one of power some of the armor and amulet stats change, ie thunder resistance becomes water resistance, not sure if its a bug atm

                          • Anonymous

                            23 Sep 2017 07:36  

                            I'm at like 40 hours of gameplay and still have yet to find a single bone so that I could make bone dust > pixie dust I even double checked the skull cave again and every single "pile of bones" has no bones like wtf? Does anyone know what I'm doing wrong?

                            • Anonymous

                              21 Sep 2017 19:01  

                              Once I got to a higher level, the "Dwarf Worker" at the Paladin Checkpoint in Reaper's Coast sold some Pouches Superior Pixie Dust, quite expensive though like 2k gold a piece.

                              2x Large Rune + 1x Superior Pixie Dust = 1x Giant Rune

                              • Anonymous

                                20 Sep 2017 01:04  

                                First of all - 3Xrune doesn't work. Don't know if since now, or always.
                                Second of all, Superior pixie dust is made from superior stardust, which is made from superior stardust herb. I bought it on bloodmoon island.

                                Anyone knows what to do with ALIEN LIFE ESSENCE?

                                • Anonymous

                                  19 Sep 2017 23:15  

                                  2 small/medium/ # pixie dust= rune of the 1 higher tier. 2 large runes #pouch of superior pixie dust= giant rune

                                  • Anonymous

                                    Runes [Divinity OS 2 Wiki]19 Sep 2017 10:12  

                                    im right at the end of the game at 60 hours and i still have no idea how the crafting system works.. about the only thing ive figured out (by guessing) is the runes are all 2 runes 1 dust and that frames are extremely rare... im sure theres some way to craft them out of scraps.... but who knows because ive only gotten a handful of recipes and ive picked up almost every book ive come across.

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