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Runes in Divinity: Original Sin 2 can be found on this page. You can enchant Weapons and Armor with Runes to increase their effectiveness. You can also combine Runes to make a more powerful version. For example if you combine 2 Small Frost Runes with pixie dust, you will gain 1 Medium Frost Rune.

 

Runes

Final Product

Ingredient 1

Ingredient 2

Ingredient 3

Weapon Slot Effects

Armor Slot Effects

Amulet Slot Effects

Small Flame Rune Wood Oil Pixie Dust +9% damage as Fire damage Fire Resistance: +6% Critical Chance: +3%
Small Thunder Rune Water Gold Pixie Dust +9% damage as Air damage Air Resistance +6%  Dodging: +3%
Small Frost Rune Water Metal Pixie Dust +9% damage as Water damage Water Resistance: +6% Movement: +0.25
Small Rock Rune Rock Beer Pixie Dust +9% damage as Earth damage Earth Resistance: +6% Maximum Vitality: +11
Small Venom Rune Bone Poison Pixie Dust +9% damage as Poison damage Poison Resistance: +6% Accuracy: +5%
Small Masterwork Rune Livewood Log Wine Pixie Dust +9% damage as Physical damage  Maximum Physical Armour: +10%  Maximum Magic Armour: +10%
Medium Flame Rune Small Flame Rune Small Flame Rune Pixie Dust +11% damage as Fire damage Fire Resistance: +9% Critical Chance: +6%
Medium Thunder Rune Small Thunder Rune Small Thunder Rune Pixie Dust +11% damage as Air damage Air Resistance: +9% Dodging: +4%
Medium Frost Rune Small Frost Rune Small Frost Rune Pixie Dust +11% damage as Water damage Water Resistance: +9% Movement: +0.5
Medium Rock Rune Small Rock Rune Small Rock Rune Pixie Dust +11% damage as Earth damage Earth Resistance: +9% Maximum Vitality: +28
Medium Venom Rune Small Venom Rune Small Venom Rune Pixie Dust +11% damage as Poison damage Poison Resistance: +9% Accuracy: +8%
Medium Masterwork Rune Small Masterwork Rune Small Masterwork Rune Pixie Dust +11% damage as Physical damage Maximum Physical Armour: +20% Maximum Magic Armour: +20%
Large Flame Rune Medium Flame Rune Medium Flame Rune Pixie Dust  +13% damage as Fire damage Fire Resistance: +12% Critical Chance: +9%
Large Thunder Rune Medium Thunder Rune Medium Thunder Rune Pixie Dust  +13% damage as Air damage Air Resistance: +12%  Dodging: +5%
Large Frost Rune Medium Frost Rune Medium Frost Rune Pixie Dust +13% damage as Water damage Water Resistance: +12% Movement: +0.75
Large Rock Rune Medium Rock Rune Medium Rock Rune Pixie Dust +13% damage as Earth damage Earth Resistance: +12% Maximum Vitality: +84
Large Venom Rune Medium Venom Rune Medium Venom Rune Pixie Dust +13% damage as Poison damage Poison Resistance: +12% Accuracy: +8%
Large Masterwork Rune Medium Masterwork Rune Medium Masterwork Rune Pixie Dust +13% damage as Physical damage  Maximum Physical Armour: +30%  Maximum Magic Armour: +30%
Giant Flame Rune Large Flame Rune Large Flame Rune Pouch Of Superior Pixie Dust  +15% damage as Fire damage Fire Resistance: +15% Critical Chance: +12%
Giant Thunder Rune Large Thunder Rune Large Thunder Rune Pouch Of Superior Pixie Dust +15% damage as Air damage Air Resistance: +15% Dodging: +6%
Giant Frost Rune Large Frost Rune Large Frost Rune Pouch Of Superior Pixie Dust +15% damage as Water damage Water Resistance: +15% Movement: +1
Giant Rock Rune Large Rock Rune Large Rock Rune Pouch Of Superior Pixie Dust +15% damage as Earth damage Earth Resistance: +15% Maximum vitality: +203
Giant Venom Rune Large Venom Rune Large Venom Rune Pouch Of Superior Pixie Dust +15% damage as Poison damage Poison Resistance: +15% Accuracy: +16%
Giant Masterwork Rune Large Masterwork Rune Large Masterwork Rune Pouch Of Superior Pixie Dust +15% damage as Physical damage Maximum Physical Armour: +40% Maximum Magic Armour: +40%
Small Flame Rune Of Power Small Flame Rune Rune Frame Of Power        
Medium Flame Rune Of Power Medium Flame Rune Rune Frame Of Power        
Large Flame Rune Of Power Large Flame Rune Rune Frame Of Power        
Small Frost Rune Of Power Small Frost Rune Rune Frame Of Power        
Medium Frost Rune Of Power Medium Frost Rune Rune Frame Of Power        
Large Frost Rune Of Power Large Frost Rune Rune Frame Of Power        
Small Thunder Rune Of Power

Small Thunder Rune

Rune Frame Of Power        
Medium Thunder Rune Of Power

Medium Thunder Rune

Rune Frame Of Power        
Large Thunder Rune Of Power

Large Thunder Rune

Rune Frame Of Power        
Small Rock Rune Of Power

Small Rock Rune

Rune Frame Of Power        
Medium Rock Rune Of Power Medium Rock Rune Rune Frame Of Power        
Large Rock Rune Of Power Large Rock Rune Rune Frame Of Power        
Small Venom Rune Of Power Small Venom Rune Rune Frame Of Power        
Medium Venom Rune Of Power Medium Venom Rune Rune Frame Of Power        
Large Venom Rune Of Power Large Venom Rune Rune Frame Of Power        
Mystical Giant Flame Rune Mystical Rune Frame Giant Flame Rune   Ranged: +1 Huntsman: +1 Pyrokinetic: +1
+15% damage as Fire damage Fire Resistance +15% Critical Chance: +12%
Mystical Giant Thunder Rune Mystical Rune Frame Giant Thunder Rune   Dual Wielding: +1 Scoundrel: +1 Aerothurge: +1
+11% damage as Air damage Water Resistance: +15% Movement: +1
Mystical Giant Venom Rune Mystical Rune Frame Giant Venom Rune   Perserverance: +1 Summoning: +1 Necromancer: +1
+15% damage as Poison damage Poison Resistance: +15% Accuracy: +16%
Mystical Giant Frost Rune Mystical Rune Frame Giant Frost Rune   Single-Handed: +1 Leadership: +1 Hydrosophist: +1
+15% damage as Water damage Air Resistance: +15% Dodging: +6%
Mystical Giant Masterwork Rune Mystical Rune Frame Giant Masterwork Rune   Wits: +3 Constitution: +3 Memory: +3
+15% damage as Physical damage Maximum Physical Armour +40% Maximum Magic Armour: +40%
Mystical Giant Rock Rune Mystical Rune Frame Giant Rock Rune   Two-Handed: +1 Warfare: +1 Geomancer: +1
+15% damage as Earth damage Earth Resistance: +15% Maximum Vitality: +203
Giant Flame Rune of Power Rune Frame of Power Giant Flame Rune   Intelligence: +3 Intelligence: +3 Intelligence: +3
+15% damage as Fire Damage Fire Resistance: +15% Critical Chance: +12%
Giant Thunder Rune of Power Rune Frame of Power Giant Thunder Rune   Finesse: +3 Finesse: +3 Finesse: +3
+11% damage as Air damage Water Resistance: +15% Movement: +1
Giant Venom Rune of Power Rune Frame of Power Giant Venom Rune   Finesse: +3 Finesse: +3 Finesse: +3
+15% damage as Poison damage Poison Resistance: +15% Accuracy: +15%
Giant Frost Rune of Power Rune Frame of Power Giant Frost Rune   Intelligence: +3 Intelligence: +3 Intelligence: +3
+15% damage as Water damage Air Resistance: +15% Movement: +1
Giant Masterwork Rune of Power Rune Frame of Power Giant Masterwork Rune   Strength: +3 Strength: +3 Strength: +3
+15% damage as Physical damage Maximum Physical Armour: +40% Maximum Magic Armour: +40%
Giant Rock Rune of Power Rune Frame of Power Giant Rock Rune   Strength: +3 Strength: +3 Strength: +3
15% damage as Earth damage Earth Resistance: +15% Maximum vitality: +203

 




    • Anonymous

      15 Oct 2017 06:27  

      I finally realized that Runes/Source Orbs can be extracted from gears when I am lvl18, don't be a silly like me. :(

      • Anonymous

        14 Oct 2017 04:28  

        Mystical Giant Venom Rune gives 15% accuracy, not 16%. It gives 1% less than its previous state, namely the simple Giant Venom Rune.

        • Anonymous

          13 Oct 2017 18:05  

          There was a mistake with 2 runes (at least), changed it.

          Giant Frost Rune of Power - 15% Air resistance
          Giant Thunder Rune of Power - 15% Water Resistance

          • Anonymous

            10 Oct 2017 09:48  

            mystical rune plus giant frost rune for some reason gives +6% dodging instead of its own property +1movement at least in recent patch ,fixed it on the table

            • Anonymous

              07 Oct 2017 22:07  

              Bought 2x Superior Pixie Dust Pouch from potion vendor at Driftwood Market Place, each for 1800 gold. 44% discount from bartering 7 and 100% attitude (just gift some 100s gold to the trader).

              • Anonymous

                07 Oct 2017 16:55  

                Can anyone tell me what Metal items work for where it says Metal + Water + Pixie dust. I have tried a bunch of different items and no luck, but i dont want to use something valuable if something cheap will do the trick.

                • Anonymous

                  04 Oct 2017 20:00  

                  there are some mistakes, regarding the last columns, some stats are switched : mystical/power of giant frost runes / giant thunder runes
                  Frost runes give movement and thunder give dodging.

                  • Anonymous

                    27 Sep 2017 11:15  

                    when upgrading a rune to a rune one of power some of the armor and amulet stats change, ie thunder resistance becomes water resistance, not sure if its a bug atm

                    • Anonymous

                      23 Sep 2017 07:36  

                      I'm at like 40 hours of gameplay and still have yet to find a single bone so that I could make bone dust > pixie dust I even double checked the skull cave again and every single "pile of bones" has no bones like wtf? Does anyone know what I'm doing wrong?

                      • Anonymous

                        21 Sep 2017 19:01  

                        Once I got to a higher level, the "Dwarf Worker" at the Paladin Checkpoint in Reaper's Coast sold some Pouches Superior Pixie Dust, quite expensive though like 2k gold a piece.

                        2x Large Rune + 1x Superior Pixie Dust = 1x Giant Rune

                        • Anonymous

                          20 Sep 2017 01:04  

                          First of all - 3Xrune doesn't work. Don't know if since now, or always.
                          Second of all, Superior pixie dust is made from superior stardust, which is made from superior stardust herb. I bought it on bloodmoon island.

                          Anyone knows what to do with ALIEN LIFE ESSENCE?

                          • Anonymous

                            19 Sep 2017 23:15  

                            2 small/medium/ # pixie dust= rune of the 1 higher tier. 2 large runes #pouch of superior pixie dust= giant rune

                            • Anonymous

                              Runes [Divinity OS 2 Wiki]19 Sep 2017 10:12  

                              im right at the end of the game at 60 hours and i still have no idea how the crafting system works.. about the only thing ive figured out (by guessing) is the runes are all 2 runes 1 dust and that frames are extremely rare... im sure theres some way to craft them out of scraps.... but who knows because ive only gotten a handful of recipes and ive picked up almost every book ive come across.

                              • Anonymous

                                18 Sep 2017 02:03  

                                cannot seem to get the giant rune crafting to work, using 2 large runes of same types in different slots + pixie dust. example would look like large fire +large fire+ pixie dust

                                • Anonymous

                                  17 Sep 2017 23:09  

                                  You need three ingredients it clearly states. To make just put 1 each in different slot and then press combine.
                                  2 small runes AND pixie dust.to get medium rune
                                  OR 3 small runes to make a large rune
                                  OR 3 medium runes to make a Giant rune.

                                  • Anonymous

                                    17 Sep 2017 16:17  

                                    When i try to combine 2 runes (same type) to make a medium it doesnt work. What am i doing wrong? please help

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