Runes - Divinity Original Sin 2

Runes in Divinity: Original Sin 2 can be found on this page.

Runes

You can enchant Weapons and Armor with Runes to imbue or amplify their current state for resistances, attribute points, combat points, stat buffs, or varying damage types. 

Tips

These are preliminary tips before you attempt to begin accumulating runes and craft higher tiers.

• Runes may be freely slotted and removed as they are not destroyed upon extraction.
  
  • Why does this matter? It's efficient to accumulate a small quantity of higher tier runes.
• Runes and Frames will appear periodically in a Trader's inventory.
  
  • Typically this is the same person.
• Frames may not be reused.
  • Why does this matter? Placing frames on low tier runes may affect availability of frames when higher tier runes become available.
• Masterwork Runes in Items increase the Physical/Magic Armor of that item.
  • This means useing a Masterwork Runes on a Armor pieces with low physical armor is a waste of a runeslot (unless you just want 3 Strenght). 

Relevant Items

Rune Variations

Final Product	Ingredient 1	Ingredient 2	Ingredient 3	Weapon Slot Effects	Armor Slot Effects	Amulet/Ring Slot Effects
Source Orb	-- Cannot --	-- be --	-- crafted --	Venomous Aura	Mass Cleanse Wounds	Evasive Aura
Small Flame Rune	Any Wood	Any Oil Source	Pixie Dust	+9% damage as Fire damage	Fire Resistance: +5%	Critical Chance: +3%
Small Frost Rune	Any Water Source	Any Metal Item	Pixie Dust	+9% damage as Water damage	Water Resistance: +5%	Movement: +0.25
Small Masterwork Rune	Livewood Log	Any Wine Source	Pixie Dust	+9% damage as Physical damage	Maximum Physical Armour: +9%	Maximum Magic Armour: +9%
Small Rock Rune	Any Rock	Any Beer Source	Pixie Dust	+9% damage as Earth damage	Earth Resistance: +5%	Maximum Vitality: +9
Small Thunder Rune	Any Water Source	Any Gold Item	Pixie Dust	+9% damage as Air damage	Air Resistance +5%	Dodging: +3%
Small Venom Rune	Any Bone	Any Poison Source	Pixie Dust	+9% damage as Poison damage	Poison Resistance: +5%	Accuracy: +5%
-	-	-	-	-	-	-
Medium Flame Rune	Small Flame Rune	Small Flame Rune	Pixie Dust	+11% damage as Fire damage	Fire Resistance: +7%	Critical Chance: +4%
Medium Frost Rune	Small Frost Rune	Small Frost Rune	Pixie Dust	+11% damage as Water damage	Water Resistance: +7%	Movement: +0.5
Medium Masterwork Rune	Small Masterwork Rune	Small Masterwork Rune	Pixie Dust	+11% damage as Physical damage	Maximum Physical Armour: +13%	Maximum Magic Armour: +13%
Medium Rock Rune	Small Rock Rune	Small Rock Rune	Pixie Dust	+11% damage as Earth damage	Earth Resistance: +7%	Maximum Vitality: +23
Medium Thunder Rune	Small Thunder Rune	Small Thunder Rune	Pixie Dust	+11% damage as Air damage	Air Resistance: +7%	Dodging: +4%
Medium Venom Rune	Small Venom Rune	Small Venom Rune	Pixie Dust	+11% damage as Poison damage	Poison Resistance: +7%	Accuracy: +8%
-	-	-	-	-	-	-
Large Flame Rune	Medium Flame Rune	Medium Flame Rune	Pixie Dust	+13% damage as Fire damage	Fire Resistance: +9%	Critical Chance: +5%
Large Frost Rune	Medium Frost Rune	Medium Frost Rune	Pixie Dust	+13% damage as Water damage	Water Resistance: +9%	Movement: +0.75
Large Masterwork Rune	Medium Masterwork Rune	Medium Masterwork Rune	Pixie Dust	+13% damage as Physical damage	Maximum Physical Armour: +17%	Maximum Magic Armour: +17%
Large Rock Rune	Medium Rock Rune	Medium Rock Rune	Pixie Dust	+13% damage as Earth damage	Earth Resistance: +9%	Maximum Vitality: +84
Large Thunder Rune	Medium Thunder Rune	Medium Thunder Rune	Pixie Dust	+13% damage as Air damage	Air Resistance: +9%	Dodging: +5%
Large Venom Rune	Medium Venom Rune	Medium Venom Rune	Pixie Dust	+13% damage as Poison damage	Poison Resistance: +9%	Accuracy: +12%
-	-	-	-	-	-	-
Giant Flame Rune	Large Flame Rune	Large Flame Rune	Pouch Of Superior Pixie Dust	+15% damage as Fire damage	Fire Resistance: +11%	Critical Chance: +6%
Giant Frost Rune	Large Frost Rune	Large Frost Rune	Pouch Of Superior Pixie Dust	+15% damage as Water damage	Water Resistance: +11%	Movement: +1
Giant Masterwork Rune	Large Masterwork Rune	Large Masterwork Rune	Pouch Of Superior Pixie Dust	+15% damage as Physical damage	Maximum Physical Armour: +21%	Maximum Magic Armour: +21%
Giant Rock Rune	Large Rock Rune	Large Rock Rune	Pouch Of Superior Pixie Dust	+15% damage as Earth damage	Earth Resistance: +11%	Maximum vitality: +111
Giant Thunder Rune	Large Thunder Rune	Large Thunder Rune	Pouch Of Superior Pixie Dust	+15% damage as Air damage	Air Resistance: +11%	Dodging: +6%
Giant Venom Rune	Large Venom Rune	Large Venom Rune	Pouch Of Superior Pixie Dust	+15% damage as Poison damage	Poison Resistance: +11%	Accuracy: +16%
-	-	-	-	-	-	-
Small Flame Rune Of Power	Small Flame Rune	Rune Frame Of Power		Intelligence: +1 +9% damage as Fire Damage	Intelligence: +1 Fire Resistance: +5%	Intelligence: +1 Critical Chance: +3%
Medium Flame Rune Of Power	Medium Flame Rune	Rune Frame Of Power		Intelligence: +2 +11% damage as Fire Damage	Intelligence: +2 Fire Resistance: +7%	Intelligence: +2 Critical Chance: +4%
Large Flame Rune Of Power	Large Flame Rune	Rune Frame Of Power		Intelligence: +2 +13% damage as Fire Damage	Intelligence: +2 Fire Resistance: +9%	Intelligence: +2 Critical Chance: +5%
Giant Flame Rune of Power	Giant Flame Rune	Rune Frame Of Power		Intelligence: +3 +15% damage as Fire Damage	Intelligence: +3 Fire Resistance: +11%	Intelligence: +3 Critical Chance: +6%
-	-	-	-	-	-	-
Small Frost Rune Of Power	Small Frost Rune	Rune Frame Of Power		Intelligence: +1 +9% damage as Water damage	Intelligence: +1 Water Resistance: +5%	Intelligence: +1 Movement: +0.25
Medium Frost Rune Of Power	Medium Frost Rune	Rune Frame Of Power		Intelligence: +2 +11% damage as Water damage	Intelligence: +2 Water Resistance: +7%	Intelligence: +2 Movement: +0.5
Large Frost Rune Of Power	Large Frost Rune	Rune Frame Of Power		Intelligence: +2 +13% damage as Water damage	Intelligence: +2 Water Resistance: +9%	Intelligence: +2 Movement: +0.75
Giant Frost Rune of Power	Giant Frost Rune	Rune Frame of Power		Intelligence: +3 +15% damage as Water damage	Intelligence: +3 Water Resistance: +11%	Intelligence: +3 Movement: +1
-	-	-	-	-	-	-
Small Thunder Rune Of Power	Small Thunder Rune	Rune Frame Of Power		Finesse: +1 +9% damage as Air damage	Finesse: +1 Air Resistance: +5%	Finesse: +1 Dodging: +3%
Medium Thunder Rune Of Power	Medium Thunder Rune	Rune Frame Of Power		Finesse: +2 +11% damage as Air damage	Finesse: +2 Air Resistance: +7%	Finesse: +2 Dodging: +4%
Large Thunder Rune Of Power	Large Thunder Rune	Rune Frame Of Power		Finesse: +2 +13% damage as Air damage	Finesse: +2 Air Resistance: +9%	Finesse: +2 Dodging: +5%
Giant Thunder Rune of Power	Giant Thunder Rune	Rune Frame of Power		Finesse: +3 +15% damage as Air damage	Finesse: +3 Air Resistance: +11%	Finesse: +3 Dodging: +6%
-	-	-	-	-	-	-
Small Rock Rune Of Power	Small Rock Rune	Rune Frame Of Power		Strength: +1 11% damage as Earth damage	Strength: +1 Earth Resistance: +5%	Strength: +1 Maximum vitality: +11
Medium Rock Rune Of Power	Medium Rock Rune	Rune Frame Of Power		Strength: +2 11% damage as Earth damage	Strength: +2 Earth Resistance: +7%	Strength: +2 Maximum vitality: +28
Large Rock Rune Of Power	Large Rock Rune	Rune Frame Of Power		Strength: +2 13% damage as Earth damage	Strength: +2 Earth Resistance: +9%	Strength: +2 Maximum vitality: +84
Giant Rock Rune of Power	Giant Rock Rune	Rune Frame of Power		Strength: +3 15% damage as Earth damage	Strength: +3 Earth Resistance: +11%	Strength: +3 Maximum vitality: +111
-	-	-	-	-	-	-
Small Venom Rune Of Power	Small Venom Rune	Rune Frame Of Power		Finesse: +1 +9% damage as Poison damage	Finesse: +1 Poison Resistance: +5%	Finesse: +1 Accuracy: +5%
Medium Venom Rune Of Power	Medium Venom Rune	Rune Frame Of Power		Finesse: +2 +11% damage as Poison damage	Finesse: +2 Poison Resistance: +7%	Finesse: +2 Accuracy: +8%
Large Venom Rune Of Power	Large Venom Rune	Rune Frame Of Power		Finesse: +2 +13% damage as Poison damage	Finesse: +2 Poison Resistance: +9%	Finesse: +2 Accuracy: +8%
Giant Venom Rune of Power	Giant Venom Rune	Rune Frame of Power		Finesse: +3 +15% damage as Poison damage	Finesse: +3 Poison Resistance: +11%	Finesse: +3 Accuracy: +15%
-	-	-	-	-	-	-
Small Masterwork Rune of Power	Small Masterwork Rune	Rune Frame of Power		Strength: +1 +9% damage as Physical damage	Strength: +1 Maximum Physical Armour: +9%	Strength: +1 Maximum Magic Armour: +9%
Medium Masterwork Rune of Power	Medium Masterwork Rune	Rune Frame of Power		Strength: +2 +11% damage as Physical damage	Strength: +2 Maximum Physical Armour: +13%	Strength: +2 Maximum Magic Armour: +13%
Large Masterwork Rune of Power	Large Masterwork Rune	Rune Frame of Power		Strength: +2 +13% damage as Physical damage	Strength: +2 Maximum Physical Armour: +17%	Strength: +2 Maximum Magic Armour: +17%
Giant Masterwork Rune of Power	Giant Masterwork Rune	Rune Frame of Power		Strength: +3 +15% damage as Physical damage	Strength: +3 Maximum Physical Armour: +21%	Strength: +3 Maximum Magic Armour: +21%
-	-	-	-	-	-	-
Mystical Giant Flame Rune	Giant Flame Rune	Mystical Rune Frame		Ranged: +1 +15% damage as Fire damage	Huntsman: +1 Fire Resistance +11%	Pyrokinetic: +1 Critical Chance: +6%
Mystical Giant Thunder Rune	Giant Thunder Rune	Mystical Rune Frame		Dual Wielding: +1 +15% damage as Air damage	Scoundrel: +1 Air Resistance: +11%	Aerothurge: +1 Dodging: +6%
Mystical Giant Venom Rune	Giant Venom Rune	Mystical Rune Frame		Perserverance: +1 +15% damage as Poison damage	Summoning: +1 Poison Resistance: +11%	Necromancer: +1 Accuracy: +16%
Mystical Giant Frost Rune	Giant Frost Rune	Mystical Rune Frame		Single-Handed: +1 +15% damage as Water damage	Leadership: +1 Water Resistance: +11%	Hydrosophist: +1 Movement: +1
Mystical Giant Masterwork Rune	Giant Masterwork Rune	Mystical Rune Frame		Wits: +3 +15% damage as Physical damage	Constitution: +3 Maximum Physical Armour +21%	Memory: +3 Maximum Magic Armour: +21%
Mystical Giant Rock Rune	Giant Rock Rune	Mystical Rune Frame		Two-Handed: +1 +15% damage as Earth damage	Warfare: +1 Earth Resistance: +11%	Geomancer: +1 Maximum Vitality: +111

 Version History:

v3.0.XXX.XXX:

• Corrected masterwork runes armor and amulet slot effects

v3.0.158.595:

• Fixed Rune screen not updating correctly when switching characters in controller mode

v3.0.150.188:

• Framed Frost runes and Framed Thunder runes now have the correct bonuses
• Improved tooltips for runes

v3.0.146.559:

• In the rune screen, you can now see all runes in all your party members’ inventories

v3.0.143.324:

• Reverted a runeslot change that was released too soon. [Undo 3.0.143.148]

v3.0.143.148:

• Rune slots are now limited to one slot per item